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FADD

Gene

2 papers3 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Massachusetts Institute of Technology and 2 more
  • Animals2

Effects

3

Cellular senescence

upin mice1

1 study

  1. FADD induces cellular senescence in mice.

    “FADD-D mice exhibited premature aging-like phenotypes, including DNA damage, cellular senescence, and shortened lifespan.”

    Animalsin FADD-D mice

    A critical role of Fas-associated protein with death domain phosphorylation in intracellular reactive oxygen species homeostasis and aging

    Antioxidants & redox signaling6 Mar 2014

More on Cellular senescence

Oxidative stress and ROS signalling

upin mice1

1 study

  1. FADD increases oxidative stress and ROS signalling in mice.

    “In FADD-D mice, the constitutive FADD phosphorylation led to ROS accumulation (hydrogen peroxide [H2O2])”

    Animalsin FADD-D mice

    A critical role of Fas-associated protein with death domain phosphorylation in intracellular reactive oxygen species homeostasis and aging

    Antioxidants & redox signaling6 Mar 2014

More on Oxidative stress and ROS signalling

Lifespan

downin mice1

1 study

  1. FADD shortens lifespan in mice.

    “FADD-D mice exhibited premature aging-like phenotypes, including DNA damage, cellular senescence, and shortened lifespan.”

    Animalsconstitutive-phosphorylation mutation (FADD-D)

    A critical role of Fas-associated protein with death domain phosphorylation in intracellular reactive oxygen species homeostasis and aging

    Antioxidants & redox signaling6 Mar 2014

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