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EREG

Gene

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

  • 1 lab in 1 country
  • Humans1

Effects

4

Pain

upin mice1

1 study

  1. EREG increases pain in mice.

    “alleviated both pathological sclerosis and pain in OA mice.”

    Animalsosteoarthritis; shown by adeno-associated virus-mediated Ereg knockdown or genetic knockout

    Multiomic identification of senescent stem cell populations critical for osteoarthritis progression and therapy in subchondral bones

    Science advances18 Jul 2025

Subchondral bone sclerosis

upin mice1

1 study

  1. EREG increases subchondral bone sclerosis in mice.

    “alleviated both pathological sclerosis and pain in OA mice.”

    Animalsosteoarthritis; shown by adeno-associated virus-mediated Ereg knockdown or genetic knockoutsubchondral bone

    Multiomic identification of senescent stem cell populations critical for osteoarthritis progression and therapy in subchondral bones

    Science advances18 Jul 2025

More on Subchondral bone sclerosis

Cellular senescence

upin mice1

1 study

  1. EREG increases cellular senescence in mice.

    “genetic knockout in mice, significantly suppressed senescence of EGFR+ MDSPCs in subchondral bone”

    Animalsosteoarthritis; shown by adeno-associated virus-mediated Ereg knockdown or genetic knockoutEGFR+ mesenchyme-derived stem/progenitor cells in subchondral bone

    Multiomic identification of senescent stem cell populations critical for osteoarthritis progression and therapy in subchondral bones

    Science advances18 Jul 2025

More on Cellular senescence

Osteogenesis

upin cells1

1 study

  1. EREG increases osteogenesis in cells.

    “In vitro and in vivo experiments demonstrated that EREG promotes senescence and excessive osteogenesis in EGFR+ MDSPCs.”

    CellsEGFR+ mesenchyme-derived stem/progenitor cells

    Multiomic identification of senescent stem cell populations critical for osteoarthritis progression and therapy in subchondral bones

    Science advances18 Jul 2025

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