ech-2

ech-2 decreases PVD neuronal degeneration in worms.

“Aβ expression accelerated age-dependent PVD degeneration, whereas ech-2 knockdown abolished this Aβ-induced effect.”

Model organismsin human Aβ1-42-expressing backgroundPVD neurons

Functional Analysis of Late-Onset Alzheimer's Disease Risk Genes in Caenorhabditis elegans Identifies Regulators of Neuronal Aging

bioRxiv : the preprint server for biology·30 Mar 2026Preprint

ech-2 improves short-term memory in worms.

“In behavioral assays, ech-2 knockdown, targeting an enoyl-CoA-hydratase, enhanced short-term memory during early stages of aging.”

Model organismsRNAi knockdown

Functional Analysis of Late-Onset Alzheimer's Disease Risk Genes in Caenorhabditis elegans Identifies Regulators of Neuronal Aging

bioRxiv : the preprint server for biology·30 Mar 2026Preprint