ABI3

1. ABI3 induces pyroptosis in mice.

   “The variant also caused microglial loss via apoptosis and pyroptosis”

   Animalsrequiring aging and human Aβ

   Abi3S212F Alzheimer's disease variant alters plaque structure and disrupts microglia

   Alzheimer's & dementia : the journal of the Alzheimer's Association·1 May 2026

More on Pyroptosis

1. ABI3 induces apoptosis in mice.

   “The variant also caused microglial loss via apoptosis and pyroptosis”

   Animalsrequiring aging and human Aβ

   Abi3S212F Alzheimer's disease variant alters plaque structure and disrupts microglia

   Alzheimer's & dementia : the journal of the Alzheimer's Association·1 May 2026

More on Apoptosis

1. ABI3 decreases microglia in mice.

   “The variant also caused microglial loss via apoptosis and pyroptosis”

   Animalsrequiring aging and human Aβ

   Abi3S212F Alzheimer's disease variant alters plaque structure and disrupts microglia

   Alzheimer's & dementia : the journal of the Alzheimer's Association·1 May 2026

1. ABI3 decreases dense-core burden in mice.

   “selectively lowering dense-core burden without affecting diffuse or total Aβ”

   Animalsin humanized amyloid beta mouse models

   Abi3S212F Alzheimer's disease variant alters plaque structure and disrupts microglia

   Alzheimer's & dementia : the journal of the Alzheimer's Association·1 May 2026

1. ABI3 decreases dense-core plaque compaction in mice.

   “Abi3S212F produced a dysfunctional microglial state that reduced dense-core plaque compaction”

   Animalsin humanized amyloid beta mouse models

   Abi3S212F Alzheimer's disease variant alters plaque structure and disrupts microglia

   Alzheimer's & dementia : the journal of the Alzheimer's Association·1 May 2026