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Dsup

Gene

2 papers6 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 2 countries
  • Funders: Agence Nationale de la Recherche and 7 more
  • Model organisms1
  • Cells1

Effects

5

Lifespan

upin worms1upin yeast cells1

2 studies

  1. Dsup extends lifespan in worms.

    “Tardigrade Dsup extends C. elegans life span”

    Model organisms

    Tardigrade Dsup extends C. elegans life span by impeding mitochondrial respiration and promoting oxidative stress resistance

    Science advances31 Oct 2025

  2. Dsup extends lifespan in yeast cells.

    “expression of Ramazzottius varieornatus Dsup in Saccharomyces cerevisiae reduces oxidative DNA damage and extends lifespan in response to chronic oxidative genotoxicity.”

    Cellsin response to chronic oxidative genotoxicity

    Multivalent binding of the tardigrade Dsup protein to chromatin promotes yeast survival and longevity upon exposure to oxidative damage

    Nature communications29 Sep 2025

Oxidative stress resistance

upin worms1

1 study

  1. Dsup increases oxidative stress resistance in worms.

    “enhanced oxidative stress resistance”

    Model organisms

    Tardigrade Dsup extends C. elegans life span by impeding mitochondrial respiration and promoting oxidative stress resistance

    Science advances31 Oct 2025

Radiation resistance

upin worms1

1 study

  1. Dsup increases radiation resistance in worms.

    “Transgenic worms tolerated x-ray exposure and oxidative stress without apparent toxicity”

    Model organismsx-ray exposure

    Tardigrade Dsup extends C. elegans life span by impeding mitochondrial respiration and promoting oxidative stress resistance

    Science advances31 Oct 2025

Oxidative phosphorylation

downin worms1

1 study

  1. Dsup decreases oxidative phosphorylation in worms.

    “Dsup expression markedly reduced mitochondrial respiration”

    Model organisms

    Tardigrade Dsup extends C. elegans life span by impeding mitochondrial respiration and promoting oxidative stress resistance

    Science advances31 Oct 2025

More on Oxidative phosphorylation

Oxidative DNA damage

downin yeast cells1

1 study

  1. Dsup decreases oxidative DNA damage in yeast cells.

    “expression of Ramazzottius varieornatus Dsup in Saccharomyces cerevisiae reduces oxidative DNA damage”

    Cellsin response to chronic oxidative genotoxicity

    Multivalent binding of the tardigrade Dsup protein to chromatin promotes yeast survival and longevity upon exposure to oxidative damage

    Nature communications29 Sep 2025

More on Oxidative DNA damage

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