CYFIP2

1. CYFIP2 inhibits hippo–YAP signalling in mice.

   “Mechanistically, CYFIP2 and p53 formed a positive feedback loop that promoted fibrosis by inhibiting the Hippo pathway and enhancing YAP nuclear translocation.”

   Animalsin DOCA/salt-induced hypertensive mice

   CYFIP2 deficiency ameliorates renal interstitial fibrosis through attenuating tubular senescence in hypertensive nephropathy

   Acta pharmacologica Sinica·7 May 2026

More on Hippo–YAP signalling

1. CYFIP2 increases renal interstitial fibrosis in mice.

   “Tubule-specific deletion of CYFIP2 attenuated hypertension-induced cellular senescence (reduced SA-β-gal, p53/p21, and SASP; increased Klotho) and mitigated renal dysfunction, collagen deposition, and epithelial‒mesenchymal transition (EMT).”

   Animalsin DOCA/salt-induced hypertensive mice

   CYFIP2 deficiency ameliorates renal interstitial fibrosis through attenuating tubular senescence in hypertensive nephropathy

   Acta pharmacologica Sinica·7 May 2026

More on Renal interstitial fibrosis

1. CYFIP2 increases cellular senescence in mice.

   “Tubule-specific deletion of CYFIP2 attenuated hypertension-induced cellular senescence (reduced SA-β-gal, p53/p21, and SASP; increased Klotho)”

   Animalsin hypertensive nephropathy

   CYFIP2 deficiency ameliorates renal interstitial fibrosis through attenuating tubular senescence in hypertensive nephropathy

   Acta pharmacologica Sinica·7 May 2026

More on Cellular senescence