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CIRCRREB1

Gene

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

  • 1 lab in 1 country
  • Animals1

Effects

4

CDKN1A

upin cells1

1 study

  1. CIRCRREB1 increases CDKN1A in cells.

    “CircRREB1-FASN axis inhibits FGF18 and FGFR3 mediated PI3K-AKT signal transduction, then increased p21 expression.”

    Cellschondrocytes

    CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications

    Nature communications28 Aug 2023

More on CDKN1A

PI3K–AKT signalling

downin cells1

1 study

  1. CIRCRREB1 inhibits PI3K–AKT signalling in cells.

    “CircRREB1-FASN axis inhibits FGF18 and FGFR3 mediated PI3K-AKT signal transduction, then increased p21 expression.”

    Cellschondrocytes

    CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications

    Nature communications28 Aug 2023

More on PI3K–AKT signalling

FASN

upin cells1

1 study

  1. CIRCRREB1 increases FASN in cells.

    “CircRREB1 impedes proteasome-mediated degradation of FASN by inhibiting acetylation-mediated ubiquitination.”

    Cellschondrocytes

    CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications

    Nature communications28 Aug 2023

More on FASN

Osteoarthritis

downin mice1

1 study

  1. CIRCRREB1 decreases osteoarthritis in mice.

    “its deficiency can alleviate FASN related senescent phenotypes and osteoarthritis progression.”

    Animalsin CircRreb1-deficient micecartilage

    CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications

    Nature communications28 Aug 2023

More on Osteoarthritis

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