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CHMP2B

Gene

1 paper studies it3 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Fundación Pública Andaluza para la Gestión de la Investigación en Salud de Sevilla and 1 more
  • Humans1

Effects

2

Myocardial ischemia/reperfusion injury

upin mice1

1 study

  1. CHMP2B increases myocardial ischemia/reperfusion injury in mice.

    “Increased CHMP2B were shown to inhibit autophagic flux leading to the deterioration of MI/R injury in aged mice hearts.”

    Animalsaged mice hearts

    SIRT6 Protects Against Myocardial Ischemia-Reperfusion Injury by Attenuating Aging-Related CHMP2B Accumulation

    Journal of cardiovascular translational research

More on Myocardial ischemia/reperfusion injury

Autophagy

downin mice1

1 study

  1. CHMP2B inhibits autophagy in mice.

    “Increased CHMP2B were shown to inhibit autophagic flux leading to the deterioration of MI/R injury in aged mice hearts.”

    Animalsaged mice hearts

    SIRT6 Protects Against Myocardial Ischemia-Reperfusion Injury by Attenuating Aging-Related CHMP2B Accumulation

    Journal of cardiovascular translational research

More on Autophagy

Upstream

1

SIRT6

downin mice1

1 study

  1. SIRT6 decreases CHMP2B in mice.

    “Specific activation of SIRT6 suppressed CHMP2B accumulation and ameliorated autophagy flux in aged hearts.”

    Animalsaged hearts

    SIRT6 Protects Against Myocardial Ischemia-Reperfusion Injury by Attenuating Aging-Related CHMP2B Accumulation

    Journal of cardiovascular translational research

More on SIRT6

Latest

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