CD200R1

1. CD200R1 decreases infarct volume in mice.

   “KO-to-GFP mice showed significantly larger brain infarct volumes and worse neurobehavior deficits compared to GFP-to-KO chimeras.”

   Animalsafter 45-min transient middle cerebral artery occlusionbrainthree days post-stroke

   Peripheral CD200R signaling: A critical regulator of post-stroke inflammation in aged mice

   Brain research bulletin·13 Dec 2025

1. CD200R1 decreases IL-1β in mice.

   “KO-to-GFP mice also exhibited significantly higher levels of pro-inflammatory cytokines IL-1β and TNF-α in the ischemic brain than GFP-to-KO chimeras.”

   Animalsafter 45-min transient middle cerebral artery occlusionbrainthree days post-stroke

   Peripheral CD200R signaling: A critical regulator of post-stroke inflammation in aged mice

   Brain research bulletin·13 Dec 2025

More on IL-1β

1. CD200R1 decreases T cell infiltration in mice.

   “T cell infiltration into the brain was significantly greater in KO-to-GFP (central CD200R signaling) compared to GFP-to-KO (peripheral CD200R signaling) mice.”

   Animalsafter 45-min transient middle cerebral artery occlusionbrainthree days post-stroke

   Peripheral CD200R signaling: A critical regulator of post-stroke inflammation in aged mice

   Brain research bulletin·13 Dec 2025

More on T cell infiltration