BMAL1
GeneHomo sapiens1 paper2 findingsHGNC 701NCBI Gene 406Taxon 9606
- Cells1
Interventions
1Aicar
upin human cells1
1 study
Aicar
upin human cells1
Aicar increases BMAL1 in human cells.
CellsU2OS
AMPK lengthens the circadian clock period through NAD+-dependent regulation of Bmal1 · bioRxiv · 30 Sep 2026 · Preprint
Upstream
1NAMPT
is required forin human cells1
1 study
NAMPT
is required forin human cells1
NAMPT is required for BMAL1 in human cells.
Cellsfor AICAR-induced Bmal1 promoter modulationU2OS
AMPK lengthens the circadian clock period through NAD+-dependent regulation of Bmal1 · bioRxiv · 30 Sep 2026 · Preprint
Latest
1AMPK lengthens the circadian clock period through NAD+-dependent regulation of Bmal1
Experiments in human cells and computational modeling show that fasting sensor AMPK requires NAD+ and PGC-1-alpha to modulate cellular circadian rhythms.
bioRxiv · Vandenberghe A et al.