BCL10

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

1 lab

Cells1

Effects

Trophoblast invasion

downin human cells1

1 study

BCL10 inhibits trophoblast invasion in human cells.
“Functionally, BCL10 overexpression increased P53/P21/P16, decreased Lamin B1, enhanced SA-β-gal activity, and inhibited invasion, while siRNA-mediated knockdown reversed these changes.”
CellsH2O2-induced senescence model; BCL10 overexpression and siRNA-mediated knockdownHTR-8/SVneo100 μM H2O2
A protein raised aging markers in lab-grown placental cells
Journal of hypertension12 Oct 2026

Cellular senescence

upin human cells1

1 study

BCL10 increases cellular senescence in human cells.
“Functionally, BCL10 overexpression increased P53/P21/P16, decreased Lamin B1, enhanced SA-β-gal activity, and inhibited invasion, while siRNA-mediated knockdown reversed these changes.”
CellsH2O2-induced senescence model; BCL10 overexpression and siRNA-mediated knockdownHTR-8/SVneo100 μM H2O2
A protein raised aging markers in lab-grown placental cells
Journal of hypertension12 Oct 2026

Associations

Preeclampsia

upin humans1

1 study

BCL10 raises the risk of preeclampsia in humans.
“MR pinpointed BCL10 as a risk factor for PE.”
HumansMendelian randomization using GTEx eQTLsplacenta
A protein raised aging markers in lab-grown placental cells
Journal of hypertension12 Oct 2026

Latest

1 in 12 months

Journal of Hypertension3 h

A protein raised aging markers in lab-grown placental cells

Experiments using a human placental cell line also found reduced invasion into surrounding material when researchers increased the protein BCL10.Experiments using a human placental cell line also found reduced invasion into surrounding material when researchers increased the protein BCL10.

Experiments in human cellsMechanisms

Paper

BCL10

Effects

Associations

Latest

A protein raised aging markers in lab-grown placental cells

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