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ADGRL2

Gene

2 papers3 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Animals1
  • Model organisms1

Effects

3

NRF2–KEAP1 antioxidant response

upin human cells1

1 study

  1. ADGRL2 activates NRF2–KEAP1 antioxidant response in human cells.

    “Furthermore, ADGRL2 enhances antioxidative responses by increasing NRF2 activity.”

    CellsLPS treatment

    The Adhesion GPCR ADGRL2/LPHN2 Can Protect Against Cellular and Organismal Dysfunction

    CellsNov 5, 2024

More on NRF2–KEAP1 antioxidant response

Cell migration

upin human cells1

1 study

  1. ADGRL2 improves cell migration in human cells.

    “overexpression of ADGRL2 protects endothelial cells from LPS-induced activation, apoptosis, and impaired migration.”

    CellsLPS treatment

    The Adhesion GPCR ADGRL2/LPHN2 Can Protect Against Cellular and Organismal Dysfunction

    CellsNov 5, 2024

Apoptosis

downin human cells1

1 study

  1. ADGRL2 inhibits apoptosis in human cells.

    “overexpression of ADGRL2 protects endothelial cells from LPS-induced activation, apoptosis, and impaired migration.”

    CellsLPS treatment

    The Adhesion GPCR ADGRL2/LPHN2 Can Protect Against Cellular and Organismal Dysfunction

    CellsNov 5, 2024

More on Apoptosis

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