Ventricular hypertrophy

3 papers2 findings

Humans1
Animals2

Upstream

1

POLG

upin mice1

1 study

POLG induces ventricular hypertrophy in mice.
“Male and female D257A mice had biventricular hypertrophy (p<0.05).”
AnimalsmtDNA mutator mouse (POLG D257A)
Mitochondria DNA mutations cause sex-dependent development of hypertension and alterations in cardiovascular function
Journal of biomechanics31 Dec 2014

Associations

1

NOS3

upin humans1

1 study

NOS3 raises the risk of ventricular hypertrophy in humans.
“the 786T>C (rs2070744) polymorphism of the NOS3 gene significantly influenced the ventricular hypertrophy (G9) at simultaneous cumulative impact with the age factor”
Humanscumulative impact with age factormyocardiummales
Association of Variants of 786T>C (rs2070744) Polymorphism of the NOS3 Gene with Age-Dependent Electrophysiological Disorders in Myocardium
Sovremennye tekhnologii v meditsine31 Oct 2025

Trial sponsors

University Hospital, Strasbourg, France
1 trialPhase 360 people

Funding

1 grant since 2026

National Institute for Health and Care Research£2.8m

REgression in Left ventrIcular hypErtrophy and Fibrosis in Aortic Stenosis – a randomised controlled trial (RELIEF-AS)
National Institute for Health and Care ResearchUniversity College London£2.8m2026–2030

Latest

39 in 12 months

Authorea PreprintsYesterday

Systematic Review on Predictive Utility of Electrocardiographic Correlates for Cardiovascular Disease

Preprint: systematic reviewCardiovascular disease

Journal of Electrocardiology8 Oct

Graded MESA-LVH as a marker of left ventricular electrical remodeling: spectrum-based diagnosis, prognosis analysis

Cohort study of 4,644 peopleBiomarkers

International Journal of Cardiology Heart & Vasculature2 Oct

Prognostic value of different electrocardiographic criteria for left ventricular hypertrophy in Chinese community-dwelling older adults

Cohort study of 6,016 peopleLeft ventricular hypertrophy

Echocardiography1 Oct

Body Roundness Index Trajectories and Incident Left Ventricular Hypertrophy: Results of a Community-Based Study in Korea

Cohort study of 1,764 peopleLeft ventricular hypertrophy

Research Square30 Sep

Association between blood pressure fluctuation and left ventricular remodeling and the mediation role of chronic low-grade inflammation in older adults: A community-based cross-sectional study

Preprint: cross-sectional study of 548 peoplePopulations

Research in Heart Yield and Translational Medicine28 Sep

Ankle-Brachial Index as a Predictor of Cardiovascular and Cerebrovascular Events in Hypertension: A Systematic Review

Systematic review of observational studiesAnkle-brachial index

Heart Rhythm26 Sep

Electrocardiogram Abnormalities and the Risk of Out-of-Hospital Cardiac Arrest: A Nationwide Cohort Study

Cohort study in peopleCardiac arrest

Pharmacology & Therapeutics26 Sep

The rhythm of pressure: Circadian disruption and chronotherapy

ReviewInterventions

Cardiology26 Sep

Empirical Classification of T-Wave Inversion Patterns as Lower-risk or Higher-risk in Black Adults: A Wall-Based Prevalence and Outcomes Analysis from the Jackson Heart Study

Cohort study of 3,514 peopleBiomarkers

Proceedings24 Sep

Artificial intelligence-enabled detection of left ventricular hypertrophy using a single-lead electrocardiogram: a pilot study for wearable-based screening

Computational studyLeft ventricular hypertrophy