Two observational cohorts of 4,526 and 5,114 adults linked clinical estimates of faster biological aging to higher odds of the heart valve condition.Two observational cohorts of 4,526 and 5,114 adults linked clinical estimates of faster biological aging to higher odds of the heart valve condition.
What changedFaster biological aging was linked to higher odds of aortic valve narrowing in RED-CARPET (odds ratio 1.29 per standard-deviation increase)
The catchValve narrowing could precede accelerated aging; the abstract does not report measurement timing
Among 28,949 UK Biobank participants without cardiovascular disease, genetic analysis linked a fat-carrying particle to 60 proteins associated with artery disease or…Among 28,949 UK Biobank participants without cardiovascular disease, genetic analysis linked a fat-carrying particle to 60 proteins associated with artery disease or heart-valve narrowing.
Over one year, cardiac events occurred in 20.5% of patients whose scan-based heart age exceeded their actual age by at least two years, versus 5.5% otherwise.Over one year, cardiac events occurred in 20.5% of patients whose scan-based heart age exceeded their actual age by at least two years, versus 5.5% otherwise.
Over 10 years, the hazard ratio—a comparison of disease rates over time—was 1.61 for participants with the condition versus those without it.Over 10 years, the hazard ratio—a comparison of disease rates over time—was 1.61 for participants with the condition versus those without it.
