Risk of Alzheimer's disease, Parkinson's disease dementia, vascular dementia, or any dementia

1. Heart rate variability has no effect on risk of Alzheimer's disease, Parkinson's disease dementia, vascular dementia, or any dementia in humans.

   “There was no significant association between HRV and the increased risks of AD, PDD, VaD, or any dementia.”

   HumansTwo-sample Mendelian randomization; no significant association detected

   Unraveling the brain-heart axis: Mendelian randomization study on the causal relationship between heart rate variability and dementia

   Journal of Alzheimer's disease reports·3 Mar 2026

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