Renal function decline

1. Vitamin D deficiency was not clearly linked with renal function decline in humans (primary glaucoma) (HR 0.972, 95% CI 0.907-1.042).

   “risks of renal function decline did not differ (HR 0.972; 95% CI 0.907-1.042)”

   Humansprimary glaucoma5 years

   Association Between Vitamin D Deficiency and Systemic Outcomes in Patients with Glaucoma: A Real-World Cohort Study

   Nutrients·Jan 14, 2026

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1. Zilebesiran raises the risk of renal function decline in humans (RR 2.80; 95% CI 1.38 to 5.67; p < 0.01).

   “renal function decline (eGFR decrease ≥ 30%) (RR 2.80; 95% CI 1.38 to 5.67; p < 0.01).”

   Review

   Efficacy and safety of zilebesiran for inadequately controlled hypertension: a systematic review and meta-analysis

   ESC Congress 2026 abstract·Oct 26, 2026

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1. Up-and-Go Test predicts renal function decline in humans (AUC = 0.656, p < 0.001).

   “The Up and Go Test indicated a good discriminatory ability for renal function decline (AUC = 0.656, p < 0.001).”

   Humansn = 359

   Frailty Syndrome and Cardiovascular Diseases in Older People

   Healthcare (Basel, Switzerland)·Dec 13, 2025

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1. Soluble Klotho is linked with a lower risk of renal function decline in humans (competing risk analysis, independent of traditional risk factors) (HR 0.27 per 10% higher level (95% CI 0.15–0.52); 24% vs 6.2% cumulative incidence below vs above median 204.4 pg/mL).

   “a 10% higher sKlotho level reduced the incidence of the primary outcome by 12% (hazard ratio, 0.27; 95% confidence interval, 0.15 to 0.52; P < 0.001]”

   Humanscompeting risk analysis, independent of traditional risk factorskidneyper 10% higher sKlotho levelmedian 9 years follow-upn = 101

   Reduced Levels of Anti-Ageing Hormone Klotho Predict Renal Function Decline in Type 2 Diabetes

   The Journal of clinical endocrinology and metabolism·Mar 7, 2018

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