Pituitary tumor

1. Rapamycin decreases pituitary tumor in mice.

   “slowed the appearance and growth of pituitary”

   Animalsenterically released formulation (eRapa)pituitary14 mg/kg food (approx. 2.24 mg/kg body weight per day)

   Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors

   Aging·1 Feb 2013

More on Rapamycin

1. Caloric restriction has no effect on pituitary tumor in mice.

   “40-50% reductions in dietary intake, relative to an ad libitum group, started on either postnatal day 28 or 42 had little to no effect on either the frequency or growth of pituitary tumors”

   Animalsin Rb(+/-) mice40-50% reductions in dietary intake

   Minimal effects of dietary restriction on neuroendocrine carcinogenesis in Rb+/- mice

   Carcinogenesis·1 Feb 2003

More on Caloric restriction

1. Dietary restriction decreases pituitary tumor in rats.

   “Dietary restriction was effective in slowing the progression of pituitary tumor, chronic nephropathy and myopathy in anterior tibial muscle.”

   Animalsrestricted to 60% of the ad libitum intakemales

   The influence of dietary restriction on the process of age-related disorders in male Donryu rats

   Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·1 May 2000

More on Dietary restriction