Ovarian aging
Disease1 paper
Funding
National Institute on AgingUS$84.2k1 grant since 2025
Latest
33Elamipretide improves oocyte quality and restores fertility in aged mice
The peptide also boosted maturation and fertilization in aged human oocytes by activating the vitamin B6 and VEGF pathway.The peptide also boosted maturation and fertilization in aged human oocytes by activating the vitamin B6 and VEGF pathway.
Tamoxifen causes temporary ovarian disruption without altering long-term mouse aging trajectories
A new preprint shows tamoxifen-inducible mouse models remain valid for ovarian aging research despite transient disruptions to estrous cycling.A new preprint shows tamoxifen-inducible mouse models remain valid for ovarian aging research despite transient disruptions to estrous cycling.
Ovarian stiffness increases with age and tracks with declining egg yield
Researchers combined imaging, matrix profiling, and single-cell sequencing to show how ovarian fibrosis develops in women over time.Researchers combined imaging, matrix profiling, and single-cell sequencing to show how ovarian fibrosis develops in women over time.
Inhibiting CHK2 improves oocyte quality and reduces ovarian inflammation in aged mice
A multi-omic analysis shows that defective luteal resolution and CHK2-driven inflammation drive ovarian aging, but drug inhibition restores oocyte…A multi-omic analysis shows that defective luteal resolution and CHK2-driven inflammation drive ovarian aging, but drug inhibition restores oocyte maturation.
Faulty debris clearance promotes ovarian fibroinflammation in mice
Using a corpus luteum tracking system in older mice, researchers linked stalled regression to persistent tissue debris, multinucleated giant cells…Using a corpus luteum tracking system in older mice, researchers linked stalled regression to persistent tissue debris, multinucleated giant cells, and localized fibroinflammation.