1 paper2 findings
RORB and LAMP5 neurons
upin silico1
Nasu-Hakola disease increases RORB and LAMP5 neurons in silico.
“on the contrary an enrichment of RORB and LAMP5 neurons with compromised metabolic states in the disease context”
In silicoin Nasu-Hakola diseaseoccipital cortex
Cell counts may miss dementia-linked changes in human brains
bioRxiv11 Oct 2026Preprint
Upper layer CUX2 neuron
downin silico1
Nasu-Hakola disease decreases upper layer CUX2 neuron in silico.
“In OC we noticed depleted upper layer CUX2 neuron, PVALB and SST neurons”
In silicoin Nasu-Hakola diseaseoccipital cortex
Cell counts may miss dementia-linked changes in human brains
bioRxiv11 Oct 2026Preprint
An observational analysis of human brain tissue compared gene activity and cell proportions across normal cognition, disease-related aging and dementia.An observational analysis of human brain tissue compared gene activity and cell proportions across normal cognition, disease-related aging and dementia.