Major age-related noncommunicable diseases

1. Polygenic lifespan score is associated with major age-related noncommunicable diseases in humans (lowest HR ≈ 0.70, highest HR ≈ 1.20).

   “Most of the associations were time-dependent, and the hazard ratio (HR) varied over time from protective to risk-increasing.”

   HumansMost associations varied over time; Parkinson's disease was an exception.46.3% mensn = 376,753

   The association of a polygenic lifespan score with the risk of common age-related diseases and mortality

   The journals of gerontology. Series A, Biological sciences and medical sciences·18 Jul 2025

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