Intestinal dysfunction

1 paper

Animals1

Trial sponsors

The First Affiliated Hospital of Nanchang University
1 trialPhase 260 people
First Affiliated Hospital of Chengdu Medical College
1 trialPhase 1/280 people

Latest

5 in 12 months

Medicine9 Oct

Shared genetic architecture between constipation and aging-related phenotypes: Insights from large-scale genome-wide cross-trait analysis

Computational studyMechanisms

Journal of the Science of Food and Agriculture14 Aug

2'-Fucosyllactose attenuates estrogen-deficiency-associated bone loss and intestinal dysfunction in ovariectomized rats

Experiments in ratsGut and microbiome

Journal of Environmental Sciences2 Mar

Polystyrene microplastics exposure increases the disruption of intestinal barrier integrity and gut microbiota homeostasis during obesity and aging

Experiments in miceMicrobiome composition

Nutrients27 Feb

The Diet-Microbiota-Polyamine Axis in Intestinal Aging: Microbial Pathways, Functional Foods, and Physiological Implications

ReviewMicrobiome composition

Cells26 Nov

cGAS/STING Pathway Mediates Accelerated Intestinal Cell Senescence and SASP After GCR Exposure in Mice

Experiments in micecGAS–STING signalling

The Journal of Clinical Investigation17 Nov

Subcutaneous white adipose tissue-derived extracellular vesicles maintain intestinal homeostasis via IgA biosynthesis in aging mice

Experiments in miceGut and microbiome

Free Radical Biology & Medicine30 Oct

GPX4 ortholog regulates the O-GlcNAc-DDR pathway to preserve intestinal stem cell homeostasis during aging and oxidative stress

Experiments in fliesCell cycle regulation

Advanced Science28 Oct

Lactobacillus Salivarius-Derived Indole-3-Acetic Acid Promotes AHR-PARP1 Axis-Mediated DNA Repair to Mitigate Intestinal Aging

Study in peopleGut and microbiome

Aging Cell25 Nov

Asparagine prevents intestinal stem cell aging via the autophagy-lysosomal pathway

Experiments in fliesGut and microbiome