Divorce

7 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

3 independent labs in 3 countries

Funders: National Institute on Aging and 4 more

Humans6

Outcomes

Waist circumference

upin humans1

1 study

Divorce increases waist circumference in humans (1.45 cm (95% CI, 0.14 to 2.75)).
“Among men, becoming divorced was significantly associated with changes in WC (1.45 cm; 95% CI, 0.14 to 2.75), compared to men remained partnered.”
Humansmales
Metabolic Consequences of Adverse Social Transitions among Aging Adults: A Gender-Sensitive Prospective Study of the Canadian Longitudinal Study on Aging Cohort (2011-2021)
Journal of obesity & metabolic syndrome18 Dec 2025

Associations

Cardiovascular disease

upin humans1HR 1.28

1 study

Divorce raises the risk of cardiovascular disease in humans (HR 1.28, 95% CI 1.14-1.44).
“however, divorced individuals had a 28 % higher incidence (HR 1.28, 95% CI 1.14-1.44)”
Review
Marital Status as a Factor in Cardiovascular Disease Risk Stratification: A Systematic Review and Meta-Analysis.
AHA Scientific Sessions 2025 abstract3 Nov 2025