Hyperacute rejection

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Multiplex genetic modification of donor pigs

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Multiplex genetic modification of donor pigs decrease hyperacute rejection.
“Multiplex genetic modification of donor pigs, including deletion of major carbohydrate antigens and expression of human complement and coagulation regulatory proteins, has substantially mitigated hyperacute rejection.”
Reviewxenotransplantation using genetically modified donor pigskidney
Complement system in kidney transplantation: from innate immune surveillance to a therapeutic and genetic engineering target
Frontiers in immunology28 Sep 2026

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