PDS5B

2 papers3 findings

HGNC NCBI Gene Taxon

1 lab in 1 country

Funder: National Natural Science Foundation of China

Animals2

Effects

3

Meiotic defects

downin mice1

1 study

PDS5B decreases meiotic defects in mice.
“expression of exogenous PDS5B in aged oocytes partially alleviated meiotic defects associated with advanced maternal age.”
Animalsexogenous expression in aged oocytes
Insufficiency of cohesin regulatory protein PDS5B triggers meiotic failure and aneuploidy in oocytes during advanced maternal aging
Proceedings of the National Academy of Sciences of the United States of America30 Jul 2026

Female subfertility

downin mice1

1 study

PDS5B protects against female subfertility in mice.
“Knockdown or heterozygous knockout of PDS5B caused spindle assembly defects, meiotic arrest, and aneuploidy in oocytes, ultimately leading to female subfertility.”
Animalsknockdown or heterozygous knockout
Insufficiency of cohesin regulatory protein PDS5B triggers meiotic failure and aneuploidy in oocytes during advanced maternal aging
Proceedings of the National Academy of Sciences of the United States of America30 Jul 2026

More on Female subfertility

Aneuploidy

downin mice1

1 study

PDS5B prevents aneuploidy in mice.
“Knockdown or heterozygous knockout of PDS5B caused spindle assembly defects, meiotic arrest, and aneuploidy in oocytes”
Animalsknockdown or heterozygous knockout
Insufficiency of cohesin regulatory protein PDS5B triggers meiotic failure and aneuploidy in oocytes during advanced maternal aging
Proceedings of the National Academy of Sciences of the United States of America30 Jul 2026

Latest

2 in 12 months

PNAS30 Jul

Insufficiency of cohesin regulatory protein PDS5B triggers meiotic failure and aneuploidy in oocytes during advanced maternal aging

Experiments in miceCell cycle regulation

Biology Direct26 Mar

SIRT1 haploinsufficiency recapitulates age-associated subfertility through sperm α-tubulin hyperacetylation

Experiments in miceSirtuin signalling