Community-based going-out program is associated with dementia onset in humans (HR 0.57 (95% CI 0.37–0.86); absolute risk reduction 3.0% (95% CI 0.8–5.2); NNT 33 (95% CI 19–125)).
“The hazard ratio was 0.57 (95 % CI 0.37, 0.86).”
HumansEngagement versus non-engagement in Japan, after propensity score matching48-month follow-upn = 1,690
sex-specific health trajectory clustering predicts dementia onset in silico (F-score 77%).
“The proposed sex-specific models for older adult populations (>=65 years of age) outperformed the previous models with F-score of 77% and 78% for male-specific and female-specific models, respectively.”
Each standard-deviation increase in the midlife marker was linked to 0.030 standard deviations faster late-life memory decline during an 11-year follow-up.Each standard-deviation increase in the midlife marker was linked to 0.030 standard deviations faster late-life memory decline during an 11-year follow-up.
Cohort study of 1,515 adults with midlife and late-life blood samples, 11 yearsBiomarkers
Limit: The outcome was declining thinking skills, not dementia onset
Among male veterans with erectile dysfunction, drug use was associated with fewer Alzheimer dementia diagnoses than non-use, with an odds ratio of 0.91.Among male veterans with erectile dysfunction, drug use was associated with fewer Alzheimer dementia diagnoses than non-use, with an odds ratio of 0.91.
Preprint: cohort study of 878,240 male Veterans with erectile dysfunction, against PDE5 inhibitor nonusersErectile dysfunction
Limit: Advanced neurodegenerative disease may reduce treatment uptake, making users appear protected
An overall thinking score matched an established measure in classifying progression to mild cognitive impairment, with a performance score of 0.70.An overall thinking score matched an established measure in classifying progression to mild cognitive impairment, with a performance score of 0.70.
Severe visual impairment was associated with dementia onset 2.1 years earlier than normal vision in a 16-year cohort of older adults.Severe visual impairment was associated with dementia onset 2.1 years earlier than normal vision in a 16-year cohort of older adults.