Chemotherapy-induced bone loss
1 paper2 findings
- Animals1
Interventions
1Dasatinib + quercetin
downin mice1
1 study
Dasatinib + quercetin
downin mice1
Dasatinib + quercetin prevents chemotherapy-induced bone loss in mice.
“treatment with the senolytic combination dasatinib and quercetin (D + Q) selectively eliminates senescent CAR cells and BMAds, effectively preventing chemotherapy-induced bone loss.”
Animalschemotherapy-induced
Chemotherapy-induced adipo-lineage cell senescence drives bone loss
Nature communications30 Dec 2025
Upstream
1Cellular senescence
upin mice1
1 study
Cellular senescence
upin mice1
Cellular senescence increases chemotherapy-induced bone loss in mice.
“Induction of senescence within these populations promotes RANK ligand (RANKL)-mediated osteoclastogenesis, leading to significant bone loss.”
Animalsin bone marrow adipo-lineage cells
Chemotherapy-induced adipo-lineage cell senescence drives bone loss
Nature communications30 Dec 2025
Latest
2 in 12 monthsGeroScience
Targeting cellular senescence mitigates chemotherapy-induced bone loss in young and aged mice
Experiments in miceBones and joints
Nature Communications
Chemotherapy-induced adipo-lineage cell senescence drives bone loss
Experiments in miceBone loss
Scientific Reports
The adverse effects of chemotherapy on bone mass are not prevented by senolytics
Experiments in miceSenolytics
Molecular Therapy
Inhibition of C5AR1 impairs osteoclast mobilization and prevents bone loss
Experiments in animalsMechanisms