Cardiovascular Diabetology
Protein linked to opposing cardiovascular and kidney disease risks
Genetic analyses suggested blood pressure potentially accounted for 42.9–66.7% of the association between higher protein levels and cardiovascular disease risk.Genetic analyses suggested blood pressure potentially accounted for 42.9–66.7% of the association between higher protein levels and cardiovascular disease risk.
Mendelian randomizationKidney
Who was studiedPeople of European and East Asian ancestry
What changedHigher genetically predicted FGF5 was linked to higher cardiovascular disease risk but lower chronic kidney disease risk
The catchObservational associations lacked full adjustment for CKD stage, urate-lowering and antihypertensive medications, and inflammation