1 paper2 findings
Baclofen
downin humans1
Baclofen is associated with Alzheimer's disease incidence in humans.
“we identified 12 drugs associated with reduced AD incidence, including trazodone (targeting ADRA1A) and baclofen (targeting GABBR1).”
Humansmild cognitive impairmentn = 111,680
Genetic data highlight potential drug targets for Alzheimer's
Nature neuroscience8 Oct 2026
Trazodone
downin humans1
Trazodone is associated with Alzheimer's disease incidence in humans.
“we identified 12 drugs associated with reduced AD incidence, including trazodone (targeting ADRA1A) and baclofen (targeting GABBR1).”
Humansmild cognitive impairmentn = 111,680
Genetic data highlight potential drug targets for Alzheimer's
Nature neuroscience8 Oct 2026
A Mendelian randomisation analysis identified 19 candidate targets in people of European ancestry and seven in people of African ancestry.A Mendelian randomisation analysis identified 19 candidate targets in people of European ancestry and seven in people of African ancestry.