1 paper2 findings
pTau-181
downin human cells1
EPHX2P.ARG287GLN decreases pTau-181 in human cells.
“validated the protective role of p.Arg287Gln via reduced levels of EPHX2 and phosphorylated tau (pTau-181).”
CellsAlzheimer's disease; p.Arg287Gln variantinduced pluripotent stem cell-derived neurons and cerebral organoids
Genetic data highlight potential drug targets for Alzheimer's
Nature neuroscience8 Oct 2026
EPHX2
downin human cells1
EPHX2P.ARG287GLN decreases EPHX2 in human cells.
“validated the protective role of p.Arg287Gln via reduced levels of EPHX2 and phosphorylated tau (pTau-181).”
CellsAlzheimer's disease; p.Arg287Gln variantinduced pluripotent stem cell-derived neurons and cerebral organoids
Genetic data highlight potential drug targets for Alzheimer's
Nature neuroscience8 Oct 2026
A Mendelian randomisation analysis identified 19 candidate targets in people of European ancestry and seven in people of African ancestry.A Mendelian randomisation analysis identified 19 candidate targets in people of European ancestry and seven in people of African ancestry.