What does the research say about acetaminophen-induced liver injury?

Acetaminophen-induced liver injury

There are 7 papers on acetaminophen-induced liver injury in aging research: 1 observational study in people, 6 in animals. The newest story, Nov 13, 2026: “Estrogen loss reduced acetaminophen liver injury in mice”.

Disease

7 papers study it3 more mention it6 findings

1 new paper in 30 daysSee all 10 papers on acetaminophen-induced liver injury

Humans1
Animals6

Interventions

High-fat diet

downin mice1

1 study

High-fat diet protects against acetaminophen-induced liver injury in mice (Long-term estrogen deprivation and acetaminophen challenge).
“Enhancement of lipid remodeling with high-fat diet increased NRF2 signaling and hepatoprotection”
AnimalsLong-term estrogen deprivation and acetaminophen challengeliverfemales
Estrogen loss reduced acetaminophen liver injury in mice
bioRxivNov 12, 2026Preprint

Upstream

Long-term estrogen deprivation

downin mice1

1 study

Long-term estrogen deprivation protects against acetaminophen-induced liver injury in mice (Ovariectomized mice challenged with acetaminophen).
“Long-term estrogen deprivation confers protection against AP-ILI through extensive hepatic lipid remodeling”
AnimalsOvariectomized mice challenged with acetaminophenliverSix months after surgeryfemales
Estrogen loss reduced acetaminophen liver injury in mice
bioRxivNov 12, 2026Preprint

NRF2–KEAP1 antioxidant response

is required forin mice1

1 study

NRF2–KEAP1 antioxidant response is required for acetaminophen-induced liver injury in mice (urolithin a protection, shown by Nrf2 gene silencing).
“which instead was compromised with Nrf2 gene silencing both in vivo and in vitro”
Animalsurolithin a protection, shown by Nrf2 gene silencingliver
Urolithin A protects against acetaminophen-induced liver injury in mice via sustained activation of Nrf2
International journal of biological sciencesFeb 28, 2022

More on NRF2–KEAP1 antioxidant response

Funding

1 grant since 2021

National Institute of Diabetes and Digestive and Kidney Diseases$46K

Sexual dimorphism of acetaminophen-induced liver injury and regeneration
National Institute of Diabetes and Digestive and Kidney DiseasesBoston University Medical Campus$46K2021–2023

Latest

3 papers in 12 months

bioRxivNov 12

Estrogen loss reduced acetaminophen liver injury in mice

Female mice given acetaminophen six months after ovary removal showed altered liver fats and sustained activity of a stress-defense protein.Female mice given acetaminophen six months after ovary removal showed altered liver fats and sustained activity of a stress-defense protein.

Preprint: mouse studyMechanisms

Paper

Cell Reports MedicineOct 2

RNA delivery linked to enhanced liver regeneration in mice

In mice, liver-targeted messenger RNA briefly induced reprogramming proteins and was associated with enhanced regeneration after acetaminophen-induced injury.In mice, liver-targeted messenger RNA briefly induced reprogramming proteins and was associated with enhanced regeneration after acetaminophen-induced injury.

Experiments in miceInterventions

Paper

Protein and Peptide LettersJan 1