Papers on vaccine responsiveness

289 papers9 new in 30 days

Saturday, November 14

VaccineNov 14

Immunosenescence and vaccine adjuvants in older adults: from immune decline to signal reconstitution strategies

ReviewBlood and immune system

Paper

Wednesday, November 11

Science AdvancesNov 11

Uneven T cell division linked to better vaccine responses

People in an influenza vaccine trial had better responses when their dividing T cells shared cellular recycling machinery more unequally.People in an influenza vaccine trial had better responses when their dividing T cells shared cellular recycling machinery more unequally.

Human CD8⁺ T cells undergo ACD in the presence of Fc–ICAM-1.

Cohort · 12 peopleImmune response

Paper

Thursday, November 5

Research SquareNov 5

CMV Associated CD4+ TEMRA Cell Expansion and Vaccine Responsiveness in Older Nursing Home Residents

Baseline Clinical Characteristics and Prior Exposure to Common Viruses Were Not Associated with Vaccine-Induced Humoral Immune Responses in Older Nursing Home Residents.

Preprint: cohort study of 86 peopleImmune response

Paper

Tuesday, November 3

Research SquareNov 3

Inhibiting brain neurons restored immune cell production in aged mice

In experiments in aged mice, inhibiting specific brain neurons or deleting a gene involved in inflammatory signaling improved the response to a flu vaccine.In experiments in aged mice, inhibiting specific brain neurons or deleting a gene involved in inflammatory signaling improved the response to a flu vaccine.

Bone marrow with sparse versus abundant immune cells sits beneath mice and branching neurons, with inflammation clustered above the sparse region.

Preprint: mouse studyBlood and immune system

Paper

The Lancet Healthy LongevityNov 3

Frailty as a determinant of mRNA vaccine efficacy

Figure from The Lancet Healthy Longevity

ReviewInterventions

Paper

Friday, October 30

Frontiers in ImmunologyOct 30

Exercise–nutrition–myokine–mitochondrial interactions in immune aging: an immunometabolic framework for host defense

ReviewImmune response

Paper

Tuesday, October 27

Clinical and Experimental ImmunologyOct 27

T cell metabolic ageing as a factor for therapeutic research

Figure from Clinical and Experimental Immunology

CommentaryBlood and immune system

Paper

Age and AgeingOct 27

Recent research on vaccines for older adults

CommentaryInterventions

Paper

Friday, October 16

Research SquareOct 16

Vaccine patch under the tongue protected aged mice from flu

When aged mice were exposed to influenza, the patch provided 100% protection, compared with 75–80% protection from injected formulations.When aged mice were exposed to influenza, the patch provided 100% protection, compared with 75–80% protection from injected formulations.

Histological analysis of the suglingual tissue ageing.

Preprint: mouse studyInterventions

Paper

Tuesday, October 13

Cell InsightOct 13

Remodeling of innate antiviral immunity in aging

Remodeled innate antiviral responses in aging.

ReviewMechanisms

Paper

Friday, October 9

Frontiers in AgingOct 9

Age-associated remodeling of NK cell subsets, B cell subsets, and T cell surface markers in peripheral blood of healthy Chinese adults: a prospective multicolor flow cytometry study

Scatter plots of Panel 1 T cell parameters versus age.

Cross-sectional study of 146 peopleBlood and immune system

Paper

Thursday, September 24

Sleep MedicineSep 24

Sleep deprivation as a multi-system physiological stressor: A review of shared mechanisms and clinical implications

ReviewMechanisms

Paper

Signal Transduction and Targeted TherapySep 24

Targeting BIRC6 rejuvenates hematopoietic stem cell aging and immunosenescence

Upregulated BIRC6 signaling diminishes apoptotic priming in aged HSCs.

Experiments in miceBlood and immune system

Paper

Tuesday, September 22

Exploration of ImmunologySep 22

COVID-19, immunity, and vaccination: unravelling the interplay of sex, gender, age, and the exposome

ReviewCOVID-19

Paper

Friday, September 11

Science ImmunologySep 11

AMnESTI reverses age-associated lung immune decline to drive heterosubtypic protection by inactivated influenza vaccines

Experiments in miceInfluenza

Paper

Thursday, September 3

medRxivSep 3

Both ageing and frailty status impact vaccine-induced transcriptomic profiles and subsequent humoral immunity: results from the VITAL cohort

Overall post-vaccination vaccine gene expression changes for the two vaccines; (a) Principal component analysis (PCA) plots illustrating global gene expression patterns across post-vaccination…

Preprint: non-randomized trial in 148 peopleInterventions

Paper

Wednesday, August 26

VaccinesAug 26

Association Between Immunosuppressive Cell Populations and Immune Response to Influenza Vaccination in Younger and Older Adults

PMN-MDSCs and M-MDSCs are increased with age.

Non-randomized trial in 75 peopleImmune response

Paper

Saturday, August 22

Preprints.orgAug 22

Regular Blood Donation: Does It Have a Clinical Impact on Donor Health?

Preprint: reviewMechanisms

Paper

Thursday, August 20

bioRxivAug 20

Progressive deterioration of adaptive immune repertoires in Down syndrome linked to interferon hyperactivity and lymphoid tissue disorganization

Trisomy 21 causes progressive dysregulation of the B cell lineage across the lifespan.

Preprint: cross-sectional study in peopleType I interferon signaling

Paper

Thursday, August 13

Journal of Controlled ReleaseAug 13

Nanovaccines co-delivering antigen and dual TLR agonists potentiate aged immunity by orchestrating TCR repertoire

Figure from Journal of Controlled Release

Experiments in miceBlood and immune system

Paper

Frontiers in ImmunologyAug 13

Impact of exercise intervention on immune function during aging

Immunosenescence: mechanisms and clinical consequences.

ReviewExercise

Paper

Friday, August 7

Annual Review of PsychologyAug 7

Four Decades of Stress, Depression, and Close Relationships: Lessons from Psychoneuroimmunology

ReviewMechanisms

Paper

Tuesday, August 4

Research SquareAug 4

LiteVax-adjuvanted influenza vaccine induces transient interferon-driven innate activation and accelerates early IgG3 responses in older adults

Preprint: non-randomized trial in 56 peopleInfluenza

Paper

Friday, July 31

IECCMEXICOJul 31

Immunosenescence in Autoimmune Rheumatic Diseases: Mechanisms, Clinical Consequences, Biomarkers, and Emerging Therapeutic Strategies

ReviewMechanisms

Paper

bioRxivJul 31

Flu vaccine additive linked to faster antibody rises in adults

A randomized trial analysis followed 56 younger and older adults for 180 days and found no significant difference in overall antibody levels between vaccine groups.A randomized trial analysis followed 56 younger and older adults for 180 days and found no significant difference in overall antibody levels between vaccine groups.

Preprint: randomized trial · 56 peopleInterventions

Paper

Monday, July 27

Genome BiologyJul 27

Human blood cell model outperforms 35 age-assessment methods

Trained on data from 1,284 donors, the computational framework predicted age more accurately than comparison methods in tests that included independent datasets.Trained on data from 1,284 donors, the computational framework predicted age more accurately than comparison methods in tests that included independent datasets.

Computational studyBiomarkers