Research Square · Nov 4, 2026
CMV Associated CD4+ TEMRA Cell Expansion and Vaccine Responsiveness in Older Nursing Home Residents
By Dyer AH, Murphy DM, Reddy C et al.
Older adults with advanced frailty exhibit strikingly heterogeneous immune responses. In 86 nursing home residents, clinical characteristics and viral exposure were not associated with longitudinal humoral responses to SARS-CoV-2 vaccination. Rather, expansion of immunosenescent CD4 + T EMRA cells was robustly associated with poorer vaccine immunogenicity. Whilst CMV serostatus was not associated with vaccine response, it was strongly linked to CD4 + T EMRA cell expansion, implicating CMV-associated immune remodelling in vaccine response heterogeneity.