Tumor mutational burden
2 papers4 findings
- Humans1
Upstream
2Inflammation
no changein humans1
1 study
Inflammation
no changein humans1
Inflammation has no effect on tumor mutational burden in humans (partial r s = 0.07, P = 0.54).
“but not after adjustment for age and cancer type (partial r s = 0.07, P = 0.54).”
Humansadjusted for age and cancer typepaired normal and tumor tissue
Immuno-oncology technology30 Sep 2026
Age
no changein humans1
1 study
Age
no changein humans1
Age has no effect on tumor mutational burden in humans (P = 0.27).
“attenuated by adjustment for cancer type and lost significance once microsatellite instability (MSI) status, sex, and stage were added (P = 0.27).”
Humansadjusted for cancer type, MSI status, sex, and stagetumor tissuen = 153
Immuno-oncology technology30 Sep 2026
Associations
2Inflammation
upin humans1
1 study
Inflammation
upin humans1
Inflammation is associated with tumor mutational burden in humans (r s = 0.387, P < 0.001).
“Normal-tissue inflammation correlated with paired tumor TMB (protein r s =0.387, P < 0.001)”
Humansunadjustedpaired normal and tumor tissue
Immuno-oncology technology30 Sep 2026
Age
upin humans1
1 study
Age
upin humans1
Age is associated with tumor mutational burden in humans (median 4.55 compared with 2.84 mutations per megabase).
“TMB was higher in older patients (median 4.55 compared with 2.84 mutations per megabase; P < 0.001) and correlated with age (r s = 0.334, P < 0.001)”
Humansunadjustedtumor tissuen = 153
Immuno-oncology technology30 Sep 2026