TNFR-1

1. TNFR-1 is linked with a higher risk of low in all domains intrinsic capacity trajectory group in humans (compared with the robust with high vitality trajectory group) (RRR 1.46 [95% CI 1.09–1.96]).

   “TNFR-1: RRR = 1.46 [1.09 - 1.96]”

   Humanscompared with the robust with high vitality trajectory groupfour years

   Association between aging-related biomarkers and longitudinal trajectories of intrinsic capacity in older adults

   GeroScience·Aug 24, 2023

1. TNFR-1 is associated with intrinsic capacity decline in humans (longitudinal, four-domain intrinsic capacity over 4 years) (adjusted β = -1.28 (95% CI -2.29 to -0.27), P = 0.013; higher TNFR-1 associated with faster decline).

   “TNFR-1: adjusted β (95% CI) = -1.28 (-2.29 to -0.27); P = 0.013”

   Humanslongitudinal, four-domain intrinsic capacity over 4 years4 years

   Plasma inflammation-related biomarkers are associated with intrinsic capacity in community-dwelling older adults

   Journal of cachexia, sarcopenia and muscle·Jan 20, 2023

1. TNFR-1 is associated with intrinsic capacity in humans (cross-sectional, adjusted for age, sex, MAPT group allocation and educational level) (adjusted β = -6.86 (95% CI -10.25 to -3.47), P < 0.001).

   “TNFR-1: adjusted β = -6.86 (-10.25 to -3.47); P < 0.001”

   Humanscross-sectional, adjusted for age, sex, MAPT group allocation and educational level

   Plasma inflammation-related biomarkers are associated with intrinsic capacity in community-dwelling older adults

   Journal of cachexia, sarcopenia and muscle·Jan 20, 2023

1. TNFR-1 is associated with anorexia of aging in humans (cross-sectional, baseline) (OR=1.74, 95%CI=1.27-2.39).

   “TNFR1 (OR=1.74, 95%CI=1.27-2.39) and GDF-15 (OR=1.38, 95%CI=1.01-1.89) were associated with a significant increase in the odds of presenting with anorexia of aging cross-sectionally.”

   Humanscross-sectional, baselinen = 463

   Plasma Inflammatory Biomarkers and Anorexia of Ageing among Community-Dwelling Older Adults: An Exploratory Analysis of the MAPT Study

   The journal of nutrition, health & aging·Jan 1, 2023

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1. TNFR-1 is associated with progranulin in humans.

   “Progranulin was positively associated with GDF-15, TNFR-1, and MCP-1.”

   Humansafter adjustment for age, sex, education, BMI, physical activity, MAPT allocation and APOE ε4 statusn = 475

   TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study

   The journals of gerontology. Series A, Biological sciences and medical sciences·Dec 13, 2022

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1. TNFR-1 is associated with NfL in humans.

   “NfL was positively associated with GDF-15, TNFR-1, IL-6, and Hcy.”

   Humansafter adjustment for age, sex, education, BMI, physical activity, MAPT allocation and APOE ε4 statusn = 475

   TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study

   The journals of gerontology. Series A, Biological sciences and medical sciences·Dec 13, 2022

More on NfL