Tau resistance

1. Hippocampal volume is associated with tau resistance in humans (β = -0.10(0.03), p < 0.001).

   “β HV =‐0.10(0.03), p < 0.001, β EC_thickness =‐0.14(0.03), p < 0.001”

   Humansn = 1,374

   Biomarker and cognitive associates of resistance to neocortical tau pathology in a pooled cohort

   AAIC 2025 abstract·25 Dec 2025

More on Hippocampal volume

1. Preclinical Alzheimer Cognitive Composite is associated with tau resistance in humans (β = -0.29(0.02), p < 0.001).

   “Higher PACC, greater hippocampal volume and thicker entorhinal cortices were associated with lower resistance (β PACC =‐0.29(0.02), p < 0.001”

   Humansn = 1,374

   Biomarker and cognitive associates of resistance to neocortical tau pathology in a pooled cohort

   AAIC 2025 abstract·25 Dec 2025

More on Preclinical Alzheimer Cognitive Composite

1. Aβ-PET is associated with tau resistance in humans (β = -0.13(0.03), p < 0.001).

   “β Aβ =‐0.13(0.03), p <0.001”

   Humansn = 1,374

   Biomarker and cognitive associates of resistance to neocortical tau pathology in a pooled cohort

   AAIC 2025 abstract·25 Dec 2025

More on Aβ-PET

1. MTL tau-PET is associated with tau resistance in humans (β = -0.22(0.06), p < 0.001).

   “Lower MTL tau, lower Aβ, and younger age were significantly associated with higher neocortical tau resistance (β MTL =‐0.22(0.06), p < 0.001”

   Humansn = 1,374

   Biomarker and cognitive associates of resistance to neocortical tau pathology in a pooled cohort

   AAIC 2025 abstract·25 Dec 2025

More on MTL tau-PET