Tau PET burden

1. Apoe ε4 allele is linked with higher tau PET burden in humans (compared with APOE-ε3 homozygotes; across regional tau PET measures) (βstd range 0.27-0.51 across regional measures).

   “APOE-ε4 participants showed higher Aβ (βstd [95%CI]: 0.64 [0.42, 0.82], p < 0.001) and tau burden”

   Humanscompared with APOE-ε3 homozygotes; across regional tau PET measuresbrainn = 462

   Differential associations of APOE-ε2 and APOE-ε4 alleles with PET-measured amyloid-β and tau deposition in older individuals without dementia

   European journal of nuclear medicine and molecular imaging·Feb 1, 2021

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1. Physical activity is associated with tau PET burden in humans among amyloid beta-positive individuals.

   “TVPA was associated with higher tau burden among Aβ-positive individuals and lower tau burden among Aβ-negative individuals.”

   Humansamong amyloid beta-positive individualsbrain (Braak I-II subregions)

   APOE ε4 and amyloid status moderate the associations between sleep, physical activity, and tau-PET burden in cognitively unimpaired older adults

   Alzheimer's & dementia : the journal of the Alzheimer's Association·Jun 1, 2026

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1. Wake after sleep onset is associated with tau PET burden in humans among APOE ε4 carriers.

   “Greater WASO was associated with higher tau burden among APOE ε4 carriers and amyloid beta (Aβ)-positive individuals.”

   Humansamong APOE ε4 carriersbrain (Braak I-II subregions)

   APOE ε4 and amyloid status moderate the associations between sleep, physical activity, and tau-PET burden in cognitively unimpaired older adults

   Alzheimer's & dementia : the journal of the Alzheimer's Association·Jun 1, 2026

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1. Aβ42/Aβ40 is associated with tau PET burden in humans.

   “accelerated rates of Aβ42/Aβ40 decline over time were associated with greater tau burden in Braak stages I and II.”

   Humansmedial temporal lobe

   Longitudinal rate of change in CSF biomarkers is associated with subsequent tau PET burden in Braak stages I and II: Findings from the BIOCARD study

   AAIC 2025 abstract·Dec 23, 2025

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1. Total tau is associated with tau PET burden in humans.

   “steeper increases in prior p ‐tau181 and t‐tau levels and accelerated rates of Aβ42/Aβ40 decline over time were associated with greater tau burden in Braak stages I and II.”

   Humansmedial temporal lobe

   Longitudinal rate of change in CSF biomarkers is associated with subsequent tau PET burden in Braak stages I and II: Findings from the BIOCARD study

   AAIC 2025 abstract·Dec 23, 2025

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1. P-TAU181 is associated with tau PET burden in humans.

   “steeper increases in prior p ‐tau181 and t‐tau levels and accelerated rates of Aβ42/Aβ40 decline over time were associated with greater tau burden in Braak stages I and II.”

   Humansmedial temporal lobe

   Longitudinal rate of change in CSF biomarkers is associated with subsequent tau PET burden in Braak stages I and II: Findings from the BIOCARD study

   AAIC 2025 abstract·Dec 23, 2025

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1. Hippocampal mean diffusivity is associated with tau PET burden in amyloid-positive older adults.

   “increased hippocampal MD was associated with worse memory and greater tau PET burden in Braak stages II-IV, but only in individuals who were amyloid positive”

   Humansin amyloid-positive older adultshippocampusn = 52

   Tau PET Burden Is Associated With Hippocampal Microstructure and Episodic Memory in Amyloid Positive Older Adults

   Hippocampus·Sep 29, 2025

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