Amyloid PET burden

1. Hearing loss was not clearly linked with amyloid PET burden in humans (oldest-old individuals) (p=0.7).

   “In oldest-old individuals, hearing function was not associated with amyloid pathology (p=0.7)”

   Humansoldest-old individuals

   Distinct disease mechanisms may underlie cognitive decline related to hearing loss in different age groups

   Journal of neurology, neurosurgery, and psychiatry·Jan 13, 2023

1. Non-APOE GRS is associated with amyloid PET burden in APOE ε3/ε3 individuals (β = 5.88, p = 4.34 × 10−9).

   “A non-APOE GRS of top variants was strongly associated with amyloid PET levels in the MCSA (p = 4.34 × 10−9, β = 5.88)”

   Humansin APOE ε3/ε3 individualsbrain

   Combating Genetic Heterogeneity for Polygenic Prediction of Susceptibility to Brain β-Amyloid Deposition: Beyond APOE

   Neurology. Genetics·Jul 21, 2025

More on Non-APOE GRS

1. Hearing loss is associated with amyloid PET burden in humans (younger-old individuals) (p=0.0034).

   “in the younger-old individuals hearing loss was associated with higher amyloid burden (p=0.0034).”

   Humansyounger-old individuals

   Distinct disease mechanisms may underlie cognitive decline related to hearing loss in different age groups

   Journal of neurology, neurosurgery, and psychiatry·Jan 13, 2023

1. non-APOE Alzheimer's disease risk variants are associated with amyloid PET burden in humans (MCSA = 2.1%, ADNI = 4.4%).

   “However, in both cohorts the non-APOE variants uniquely contributed only modestly (MCSA = 2.1%, ADNI = 4.4%) to explaining variation in amyloid PET levels.”

   Humansbrain

   Polygenic Scores of Alzheimer's Disease Risk Genes Add Only Modestly to APOE in Explaining Variation in Amyloid PET Burden

   Journal of Alzheimer's disease : JAD·Jan 1, 2022

1. Alzheimer's disease polygenic risk score is associated with amyloid PET burden in humans (p = 1.51×10-50 (MCSA), p = 3.21×10-64 (ADNI)).

   “In aggregate, the AD risk variants were strongly associated with amyloid PET levels in the MCSA (p = 1.51×10-50) and ADNI (p = 3.21×10-64).”

   Humansbrain

   Polygenic Scores of Alzheimer's Disease Risk Genes Add Only Modestly to APOE in Explaining Variation in Amyloid PET Burden

   Journal of Alzheimer's disease : JAD·Jan 1, 2022

1. APOE is associated with amyloid PET burden in humans.

   “Known AD risk variants in APOE, PICALM, CR1, and CLU were associated with amyloid PET levels.”

   Humansbrain

   Polygenic Scores of Alzheimer's Disease Risk Genes Add Only Modestly to APOE in Explaining Variation in Amyloid PET Burden

   Journal of Alzheimer's disease : JAD·Jan 1, 2022

More on APOE