Systemic and brain proteomic aging acceleration

1. Major depressive disorder increases systemic and brain proteomic aging acceleration in humans.

   “Mendelian randomization analyses revealed a causal effect of MDD on systemic and brain proteomic aging acceleration.”

   HumansMendelian randomization analysis

   Biological aging acceleration in major depressive disorder: a multi-omics, multi-modal analyses

   Research square·28 May 2025Preprint

More on Major depressive disorder

1. Systemic and brain proteomic aging acceleration is associated with mortality in humans.

   “Systemic and brain proteomic aging acceleration were linked to higher risks of incident MDD and a greater risk of Alzheimer's disease, related dementia, and mortality”

   HumansIndividuals with major depressive disorder in UK Biobank

   Biological aging acceleration in major depressive disorder: a multi-omics, multi-modal analyses

   Research square·28 May 2025Preprint

1. Systemic and brain proteomic aging acceleration is associated with Alzheimer's disease and related dementia in humans.

   “Systemic and brain proteomic aging acceleration were linked to higher risks of incident MDD and a greater risk of Alzheimer's disease, related dementia, and mortality”

   HumansIndividuals with major depressive disorder in UK Biobank

   Biological aging acceleration in major depressive disorder: a multi-omics, multi-modal analyses

   Research square·28 May 2025Preprint

More on Alzheimer's disease and related dementia

1. Systemic and brain proteomic aging acceleration is associated with incident major depressive disorder in humans.

   “Systemic and brain proteomic aging acceleration were linked to higher risks of incident MDD”

   HumansUK Biobank

   Biological aging acceleration in major depressive disorder: a multi-omics, multi-modal analyses

   Research square·28 May 2025Preprint

More on Incident major depressive disorder