sTNFR1

1. sTNFR1 impairs cognitive function in humans.

   “Higher levels of GDF15 and TNFR1 were associated with a worse trajectory in the cognitive composite score in adjusted models.”

   Humansadjusted modelsplasma2 yearsn = 1,527

   Association between inflammatory biomarkers and the cognitive response to a multidomain intervention: secondary longitudinal analyses from the MAPT study

   GeroScience·Jan 17, 2025

1. sTNFR1 improves reproducibility in humans (ICC 0.95 vs 0.52 (short-term); 0.79 vs 0.67 (medium-term)).

   “We found that sTNFR1 was more reproducible than IL-6 over a period of weeks and months short-term and medium-term.”

   Humansmild low-grade inflammationserumweeks and months

   Soluble TNFR1 has greater reproducibility than IL-6 for the assessment of chronic inflammation in older adults: the case for a new inflammatory marker in aging

   GeroScience·Nov 23, 2023

More on Reproducibility

1. sTNFR1 mediates mortality in humans (proportion mediated: 13.0%).

   “Soluble tumour necrosis factor receptor 1, soluble triggering receptor expressed on myeloid cells 1 and soluble thrombomodulin showed the strongest correlation with ageing and explained part of the ageing-driven increase in 30-day mortality”

   HumansCOVID-19plasma30 daysn = 464

   Age-related changes in plasma biomarkers and their association with mortality in COVID-19

   The European respiratory journal·Apr 21, 2023

1. sTNFR1 predicts mortality in humans.

   “increased mortality risk was observed only in individuals with elevated sTNFR1 levels.”

   Humansserumn = 672

   Associations between circulating cell-free mitochondrial DNA, inflammatory markers, and cognitive and physical outcomes in community dwelling older adults

   Immunity & ageing : I & A·May 23, 2023

1. sTNFR1 is associated with physical function in humans (R2 = 0.25; f2 = 0.33).

   “SPPB score was associated with COPD-related sarcopenia and sTNFR1 (R2 = 0.25; f2 = 0.33).”

   Humansmultivariate analysisplasma

   Plasma levels of myokines and inflammatory markers are related with functional and respiratory performance in older adults with COPD and sarcopenia

   Experimental gerontology·May 16, 2022