Sphingolipids
Biomarker2 papers
- Humans2
Funding
National Institute on AgingUS$1m3 grants since 2022
Understanding how sphingolipid metabolism regulates mitochondrial maintenance in aging cells
National Institute on AgingVanderbilt UniversityUS$17.9k2025–2027
Sphingolipid signaling in age-associated vascular pathology
National Institute on AgingBoston Children's HospitalUS$505.5k2022–2027
Role of glial sphingolipid ceramide in aging and Alzheimer's disease
National Institute on AgingTexas A&m Agrilife ResearchUS$499.6k2024–2028
Latest
19Aged human muscle secretes an enzyme that impairs stem cell maintenance
Profiling conditioned media revealed that altered sphingolipid signaling reduces muscle stem cell pools in human cell cultures.Profiling conditioned media revealed that altered sphingolipid signaling reduces muscle stem cell pools in human cell cultures.
Myelin lipid buildup links to lysosomal defects in mice
Profiling lysosomal fractions from mouse cortex from 3 to 24 months revealed an accumulation of myelin-derived glycosphingolipids that was most…Profiling lysosomal fractions from mouse cortex from 3 to 24 months revealed an accumulation of myelin-derived glycosphingolipids that was most pronounced in microglia.
Baseline Plasma Metabolites Associated with Subsequent Response to Lifestyle Intervention in People with Prediabetes
A PPAR-gamma counterpart protects worm neurons by coordinating lipids and mitochondria
Researchers show that SEX-1 regulates sphingolipid metabolism and mitochondrial quality control in Caenorhabditis elegans, but its protective activity…Researchers show that SEX-1 regulates sphingolipid metabolism and mitochondrial quality control in Caenorhabditis elegans, but its protective activity declines with age.