There are 3 papers on spermine/spermidine ratio in aging research: 2 observational studies in people, 1 review.
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“Spermidine levels were higher (p = 0.002) and the spermine/spermidine ratio was lower (p < 0.001) in the sarcopenia group than in the non-sarcopenia group.”
- Humans2
Associations
5C-reactive protein
downin humans1
1 study
C-reactive protein
downin humans1
Spermine/spermidine ratio is associated with C-reactive protein in humans (older adults with coronary artery disease; adjusted for age and sex) (β = −0.78 mg/L; p = 0.02).
“lower high-sensitivity C-reactive protein (β = −0.78 mg/L; p = 0.02)”
Humansolder adults with coronary artery disease; adjusted for age and sexskeletal musclen = 101
ESC Congress 2026 abstract
Appendicular lean mass indexed to body mass index
upin humans1
1 study
Appendicular lean mass indexed to body mass index
upin humans1
Spermine/spermidine ratio is associated with appendicular lean mass indexed to body mass index in humans (older adults with coronary artery disease; adjusted for age and sex) (β = 0.02; p = 0.03).
“dietary spermidine intake and the intramuscular spermine/spermidine ratio were associated with higher peak VO2/kg, higher ALM/BMI and lower body fat percentage.”
Humansolder adults with coronary artery disease; adjusted for age and sexskeletal musclen = 101
ESC Congress 2026 abstract
Peak oxygen uptake per kilogram body weight
upin humans1
1 study
Peak oxygen uptake per kilogram body weight
upin humans1
Spermine/spermidine ratio is associated with peak oxygen uptake per kilogram body weight in humans (older adults with coronary artery disease; adjusted for age and sex) (β = 1.26 mL·kg−1·min−1; p < 0.001).
“higher spermine/spermidine ratio was associated with higher peakVO2/kg (β = 1.26 mL·kg−1·min−1; p < 0.001)”
Humansolder adults with coronary artery disease; adjusted for age and sexskeletal musclen = 101
ESC Congress 2026 abstract
Sarcopenia progression
downin humans1
1 study
Sarcopenia progression
downin humans1
Spermine/spermidine ratio is associated with sarcopenia progression in humans.
“the odds ratio for the spermine/spermidine ratio changed inversely with the degree of sarcopenia progression”
Humansn = 182
Whole Blood Spermine/Spermidine Ratio as a New Indicator of Sarcopenia Status in Older Adults
Biomedicines
Sarcopenia
downin humans1
1 study
Sarcopenia
downin humans1
Spermine/spermidine ratio is associated with sarcopenia in humans (p < 0.001).
“Spermidine levels were higher (p = 0.002) and the spermine/spermidine ratio was lower (p < 0.001) in the sarcopenia group than in the non-sarcopenia group.”
Humansn = 182
Whole Blood Spermine/Spermidine Ratio as a New Indicator of Sarcopenia Status in Older Adults
Biomedicines