Sodium

Biomarker1 paper

  • Humans1

Funding

National Heart, Lung, and Blood InstituteUS$2.9mNational Institute of Arthritis and Musculoskeletal and Skin DiseasesUS$323kNational Institute on AgingUS$197.1k9 grants since 2020

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Acta PhysiologicaAnimals

Klotho deficiency disrupts potassium balance in mice

In Klotho-deficient mice, renal mTORC1 activation suppressed potassium channel ROMK1 to cause hyperkalemia, which rapamycin or Klotho supplementation…In Klotho-deficient mice, renal mTORC1 activation suppressed potassium channel ROMK1 to cause hyperkalemia, which rapamycin or Klotho supplementation reversed.