Serum estradiol

1. Botanical neurokinin inhibitor showed no clear effect on serum estradiol in humans.

   “No changes in serum estradiol or liver function abnormalities were detected.”

   Human trial12 weeksn = 68

   Neurokinin pathway botanical antagonist for menopausal vasomotor symptoms: A randomized, double-blind, placebo-controlled study

   Maturitas·Jun 10, 2026

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1. Genistein increases serum estradiol in OVX-CUMS rats.

   “GEN at doses of 10 & 20-mg/kg significantly and dose dependently restores serum estradiol levels and ER-β gene expression.”

   Animalsin OVX-CUMS rats10 and 20 mg/kgfemales

   Genistein mitigates estrogen deficiency and chronic stress-induced neuronal dysfunction via targeting ER-β, oxidative stress, inflammation, and apoptosis

   Neuromolecular medicine·Mar 16, 2026

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1. Rapamycin showed no clear effect on serum estradiol in mice.

   “Despite these improvements in the somatic microenvironment, rapamycin failed to restore fertility or serum estradiol levels in reproductively aged females.”

   Animalsfemales

   Short-Term Rapamycin Mitigates the Senescence of Ovaries and Somatic Stem Cells in Multiple Organs in Reproductively Aged Mice

   FASEB journal : official publication of the Federation of American Societies for Experimental Biology·Feb 19, 2026

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1. Serum estradiol was not clearly linked with endometrial thickness in humans (p = 0.21).

   “there was no evidence of an association between ET and serum estradiol level (p = 0.21).”

   HumansPostmenopausal women with unscheduled bleeding on transdermal estradiol plus micronized progesteroneendometriumfemalesn = 92

   Endometrial thickness and pathology in postmenopausal women with bleeding on transdermal 17β-estradiol plus body-identical progesterone

   Archives of gynecology and obstetrics·Sep 4, 2025

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1. KL increases serum estradiol in mice (shown by knockout).

   “persistently diestrus estrous status (10-12 weeks), and markedly decreased serum E2”

   Animalsshown by knockoutfemales

   Alpha-Klotho-deficient female mice exhibit estrogen metabolic dysregulation and a premature ovarian insufficiency-like phenotype

   Molecular and cellular endocrinology·Mar 13, 2026

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1. Serum estradiol is associated with stratum corneum ceramide abundance and length in humans.

   “Serum oestradiol correlated with ceramide abundance and length.”

   Humansstratum corneumfemales

   Menopause induces changes to the stratum corneum ceramide profile, which are prevented by hormone replacement therapy

   Scientific reports·Dec 15, 2022

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1. Serum estradiol is associated with whole blood serotonin in humans (serum oestradiol levels ranging 30-1335 pg/ml).

   “a direct relationship was observed between serum oestradiol levels and whole blood serotonin levels (P < 0.001).”

   Humansserum oestradiol levels ranging 30-1335 pg/mlwhole bloodfemales

   Blood serotonin levels in postmenopausal women: effects of age and serum oestradiol levels

   Maturitas·Jul 1, 1993

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