What does the research say about senescent fibroblast abundance?

Senescent fibroblast abundance

There are 2 papers on senescent fibroblast abundance in aging research: none in people yet, 2 in animals. The newest story, Nov 9, 2026: “Drug pair restores saliva flow in mice modeling Sjögren’s disease”.

Biomarker

2 papers study it2 findings

1 new paper in 30 daysSee all 2 papers on senescent fibroblast abundance

“Integrative analysis of human clinical samples and scRNA-seq revealed a significant accumulation of senescent fibroblasts in pSjD salivary glands.”

JUND-DNAJB1-p21 axis drives fibroblast senescence to recruit CD4⁺ T cells in salivary gland pathogenesis of Sjögren's diseaseImmunity & ageing : I & A2026doi:10.1186/s12979-026-00590-8

Animals2

Upstream

Advanced age

downin mice1

1 study

Advanced age decreases senescent fibroblast abundance in mice (cutaneous wounds).
“Crucially, in aged wounds, we observed a lower quantity of these senescent cells”
Animalscutaneous woundswound tissue
Older mice show a weaker cell response to skin wounds
Aging cellApr 25, 2026

Associations

Primary Sjögren's disease

upin humans1

1 study

Primary Sjögren's disease is associated with senescent fibroblast abundance in humans (primary Sjögren's disease).
“Integrative analysis of human clinical samples and scRNA-seq revealed a significant accumulation of senescent fibroblasts in pSjD salivary glands.”
Humansprimary Sjögren's diseasesalivary gland
Drug pair restores saliva flow in mice modeling Sjögren’s disease
Immunity & ageing : I & AAug 11, 2026

Latest

2 papers in 12 months

Immunity & AgeingNov 9

Drug pair restores saliva flow in mice modeling Sjögren’s disease

An experiment with six female mice per group tested dasatinib and quercetin, which reduced immune-cell buildup in salivary glands.An experiment with six female mice per group tested dasatinib and quercetin, which reduced immune-cell buildup in salivary glands.

Mouse studyInterventions

Paper

Aging CellApr 25

Older mice show a weaker cell response to skin wounds

Connective-tissue cells that had stopped dividing made up 1.7% of profiled wound cells in older mice versus 4.1% in younger mice.Connective-tissue cells that had stopped dividing made up 1.7% of profiled wound cells in older mice versus 4.1% in younger mice.

Mouse studyInflammation