Senescent B cells

2 papers2 findings

Humans1
Cells1

Interventions

2

Metformin

downin human cells1

1 study

Metformin decreases senescent B cells in human cells.
“MET in vitro was able to reduce frequencies and numbers of senescent B cells”
Cellssubcutaneous adipose tissue from females with obesitysubcutaneous adipose tissue1 mMfemalesn = 8
In Vitro Treatment with Metformin Significantly Reduces Senescent B Cells Present in the Adipose Tissue of People with Obesity
The Journal of nutrition9 Oct 2024

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Early-life stress

upin humans1

1 study

Early-life stress increases senescent B cells in humans.
“ELS was associated with increased effector memory helper T cells, effector memory cytotoxic T cells, senescent T cells, senescent B cells, and IgD- memory B cells compared to non-adopted youth.”
Humanscompared to non-adopted youth
Early Life Stress Is Associated with Alterations in Lymphocyte Subsets Independent of Increased Inflammation in Adolescents
Biomolecules22 Feb 2024

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Latest

2 in 12 months

Life Medicine2 Feb

Senescent B cells regulate CD38 expression via FOXO1 in pneumonia resulting from PIK3CD (R437C) mutations

Experiments in cellsCellular senescence

Cell Reports Medicine4 Jan

Targeting senescent EGR1⁺ B cells enhances immunotherapy efficacy in esophageal squamous cell carcinoma

Cohort study in peopleEsophageal squamous cell carcinoma

Cancer Cell23 Aug

Unraveling lymphoma-induced immune senescence

CommentaryBlood and immune system

The Journal of Nutrition11 Oct

In Vitro Treatment with Metformin Significantly Reduces Senescent B Cells Present in the Adipose Tissue of People with Obesity

Experiments in human cellsMetformin

Obesity5 Apr

Adipocyte-derived inflammatory molecules induce senescent B cells through metabolic pathways

Experiments in cellsMechanisms

Biomolecules28 Mar

Early Life Stress Is Associated with Alterations in Lymphocyte Subsets Independent of Increased Inflammation in Adolescents

Cohort study of 191 peopleInflammation