RNFL thickness

Biomarker

2 papers study it26 more mention it2 findings

Humans2

Upstream

Age

downin humans1

1 study

Age decreases RNFL thickness in humans (-0.116 μm/year (95% CI, -0.133 to -0.100; p < .001)).
“Linear regression showed significant age-related decline: RNFL at -0.116 μm/year (95% CI, -0.133 to -0.100; p < .001)”
Humanshealthyretinan = 8,558
Normative Percentiles and Age-Related Change Points for RNFL and GCIPL Thickness in Healthy Korean Adults Based on Cirrus HD‑OCT
Ophthalmic epidemiologyJul 5, 2026

Associations

Schizophrenia

downin humans1

1 study

Schizophrenia is associated with RNFL thickness in humans.
“Significant negative relationships between age and RNFL thickness, macula volume, and GCL-IPL thickness were observed in the SZ group, while no significant relationships were observed in the CON group.”
Humansin schizophrenia and schizoaffective disorder patients
Retinal Neurodegeneration as a Potential Biomarker of Accelerated Aging in Schizophrenia Spectrum Disorders
Schizophrenia bulletinJul 17, 2023

Latest

11 papers in 12 months

Journal of Clinical MedicineOct 16

Impact of Insulin Resistance on Retinal Ganglion Cell Layer Structures: Findings from the Korea National Health and Nutrition Examination Survey

Cross-sectional study of 6,941 peopleInsulin resistance

Paper

Journal of NeurologyOct 16

Thinner retinal layers linked to future cardiovascular events

Thicker retinal nerve fiber layers were linked to lower cardiovascular event rates in 51,293 participants, with an adjusted hazard ratio of 0.92.Thicker retinal nerve fiber layers were linked to lower cardiovascular event rates in 51,293 participants, with an adjusted hazard ratio of 0.92.

Cohort · 49,787 peopleCardiovascular disease

Paper

Folia MorphologicaSep 26