Regional tau PET burden

1. Apoe ε2 allele was not clearly linked with regional tau PET burden in humans (compared with APOE-ε3 homozygotes).

   “but did not differ on regional tau burden or tau accumulation over time”

   Humanscompared with APOE-ε3 homozygotesbrainn = 462

   Differential associations of APOE-ε2 and APOE-ε4 alleles with PET-measured amyloid-β and tau deposition in older individuals without dementia

   European journal of nuclear medicine and molecular imaging·Feb 1, 2021

More on Apoe ε2 allele

1. MRI-based deep learning model predicts regional tau PET burden in silico (Early uptake region (Braak I–IV) and late uptake region (Braak V–VI)) (Early region: MAE 0.14 (95% CI 0.12–0.16), r = 0.72, AUC 0.87 (95% CI 0.83–0.90); late region: MAE 0.14 (95% CI 0.12–0.17), r = 0.71, AUC 0.88 (95% CI 0.84–0.91)).

   “The model achieved an MAE of 0.14 (95% confidence interval [CI]: 0.12–0.16) and r = 0.72 for an early uptake region (Braak I‐IV)”

   In silicoEarly uptake region (Braak I–IV) and late uptake region (Braak V–VI)brain

   Model predicts tau protein scan measurements from brain images

   Alzheimer's & dementia : the journal of the Alzheimer's Association·Oct 30, 2026