Young and 18-month-old mice with an altered UCHL1 protein showed less white matter injury and better sensorimotor and cognitive performance in a dementia model.Young and 18-month-old mice with an altered UCHL1 protein showed less white matter injury and better sensorimotor and cognitive performance in a dementia model.
Among 5,230 adults aged 45 and older followed for a median 9.8 years, one brain diffusion marker best predicted cognitive decline, while two best predicted dementia risk.Among 5,230 adults aged 45 and older followed for a median 9.8 years, one brain diffusion marker best predicted cognitive decline, while two best predicted dementia risk.
In an observational study, 13.8% of older adults with normal cognitive test scores had memory or thinking concerns documented in their health records.In an observational study, 13.8% of older adults with normal cognitive test scores had memory or thinking concerns documented in their health records.
Across 60 healthy younger and older adults in the UK and Belgium, researchers found shared bacterial associations with cognitive performance despite geographic microbiome…Across 60 healthy younger and older adults in the UK and Belgium, researchers found shared bacterial associations with cognitive performance despite geographic microbiome differences.
In 563 older adults in Uganda, a brief tablet-based composite score discriminated objective cognitive impairment with a c-statistic of 0.77.In 563 older adults in Uganda, a brief tablet-based composite score discriminated objective cognitive impairment with a c-statistic of 0.77.