Entorhinal cortex tau PET

1. Entorhinal cortex tau PET impairs Preclinical Alzheimer Cognitive Composite in humans.

   “In both cohorts, EC tau was associated with worse PACC performance in both NHB and NHW”

   Humansin cognitively unimpaired older adults (both NHB and NHW in ADNI and US POINTER)entorhinal cortex

   Evaluation of Alzheimer's disease biomarkers and cognition in non‐Hispanic Black and non‐Hispanic White participants in ADNI and US POINTER Imaging

   AAIC 2025 abstract·25 Dec 2025

More on Preclinical Alzheimer Cognitive Composite

1. Amyloid beta PET is associated with entorhinal cortex tau PET in humans.

   “In US POINTER, the positive Aβ‐EC tau relationship was observed in both ethnoracial groups”

   Humansin US POINTER (both NHB and NHW) and ADNI (NHW only)entorhinal cortex

   Evaluation of Alzheimer's disease biomarkers and cognition in non‐Hispanic Black and non‐Hispanic White participants in ADNI and US POINTER Imaging

   AAIC 2025 abstract·25 Dec 2025

More on Amyloid beta PET

1. p-Tau217 predicts entorhinal cortex tau PET in humans (AUROC 0.81 vs 0.70).

   “MSD p-tau217: AUROC, 0.81 vs 0.70; P = .04”

   Humanscognitively unimpaired participantsplasman = 177

   Comparison of Plasma Phosphorylated Tau Species With Amyloid and Tau Positron Emission Tomography, Neurodegeneration, Vascular Pathology, and Cognitive Outcomes

   JAMA neurology·1 Sep 2021

More on p-Tau217

1. P-TAU181 predicts entorhinal cortex tau PET in humans (AUROC 0.80 vs 0.70).

   “both MSD p-tau181 and MSD p-tau217 more accurately predicted abnormal entorhinal cortex tau PET than Simoa p-tau181 (MSD p-tau181: AUROC, 0.80 vs 0.70; P = .046”

   Humanscognitively unimpaired participantsplasman = 177

   Comparison of Plasma Phosphorylated Tau Species With Amyloid and Tau Positron Emission Tomography, Neurodegeneration, Vascular Pathology, and Cognitive Outcomes

   JAMA neurology·1 Sep 2021

More on P-TAU181