Amyloid positivity
Biomarker2 papers3 findings
- In silico2
Associations
3Hybrid CNN-transformer model
no changein silico1
1 study
Hybrid CNN-transformer model
no changein silico1
hybrid CNN-transformer model predicts amyloid positivity in silico (ROC-AUC 0.496).
In silicounder participant-disjoint validationn = 295
Hybrid CNN-Transformer Framework for Molecular Imaging-based Early Alzheimer's Disease Detection · Molecular imaging and biology · 23 Sep 2026
Brain age
upin silico1
1 study
Brain age
upin silico1
Brain age predicts amyloid positivity in silico (AUC 0.804).
In silicoLoRA adaptation from structural MRIbrain
A Generalizable Feature Extractor for Alzheimer's-Related Brain MRI Tasks · arXiv · 4 Sep 2026 · Preprint
Agreeableness
downin humans1−8% variance
1 study
Agreeableness
downin humans1−8% variance
Amyloid positivity predicts agreeableness in humans (8% of variance).
Humans4.5-yearn = 58
Abnormal FDG-PET Patterns and Amyloid Positivity Predict Personality Changes in Cognitively Preserved Individuals · Brain sciences · 30 Jul 2026
Funding
National Institute on AgingUS$243k1 grant since 2024
Latest
107Brain thinning detected before dementia in people under 65
An observational study of 292 people under 65 linked two positive Alzheimer’s-related spinal-fluid tests to earlier and more extensive thinning.An observational study of 292 people under 65 linked two positive Alzheimer’s-related spinal-fluid tests to earlier and more extensive thinning.
Blood eMTBR-tau linked to Alzheimer’s tangles at autopsy
Classification accuracy remained high (AUC=0.91–0.95) up to a decade before death, with higher sensitivity and specificity than plasma p-tau217.Classification accuracy remained high (AUC=0.91–0.95) up to a decade before death, with higher sensitivity and specificity than plasma p-tau217.
Normative brain models reveal dopamine shifts in early amyloid
In cognitively unimpaired older adults, intermediate amyloid burden showed lower dopamine-transporter deviation scores than amyloid-positive status…In cognitively unimpaired older adults, intermediate amyloid burden showed lower dopamine-transporter deviation scores than amyloid-positive status, with an adjusted difference of −0.582.